Molecular genetics, aging, and well-being: Sensitive period, accumulation, and pathway models

MJ Shanahan, SM Hofer - Handbook of aging and the social sciences, 2011 - Elsevier
Publisher Summary Aging reflects ongoing transactions between context and person across
many decades of life. Life course sociology is now central to investigations focused on the …

[HTML][HTML] Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies

J Lara, A Godfrey, E Evans, B Heaven, LJE Brown… - Maturitas, 2013 - Elsevier
Introduction Given the biological complexity of the ageing process, there is no single, simple
and reliable measure of how healthily someone is ageing. Intervention studies need a panel …

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

J Deelen, M Beekman, M Capri, C Franceschi… - …, 2013 - Wiley Online Library
Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

Biomarker signatures of aging

P Sebastiani, B Thyagarajan, F Sun, N Schupf… - Aging cell, 2017 - Wiley Online Library
Because people age differently, age is not a sufficient marker of susceptibility to disabilities,
morbidities, and mortality. We measured nineteen blood biomarkers that include …

Aging biomarkers: from functional tests to multi‐omics approaches

KS Kudryashova, K Burka, AY Kulaga… - …, 2020 - Wiley Online Library
Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

The shift of the paradigm between ageing and diseases

F Salvatore - Clinical Chemistry and Laboratory Medicine (CCLM), 2020 - degruyter.com
In the area of the Medical Sciences, the chronological age has always been, and still is, an
indicator by which we try to understand the health status of an individual. However, besides …

[HTML][HTML] A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study

Z Liu, PL Kuo, S Horvath, E Crimmins, L Ferrucci… - PLoS …, 2018 - journals.plos.org
Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …

[图书][B] Handbook of the Biology of Aging

EJ Masoro, SN Austad - 2010 - books.google.com
Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings
and discoveries in the field. This volume is part of The Handbooks of Aging series, which …

[HTML][HTML] Revisiting the hallmarks of aging to identify markers of biological age

F Guerville, P De Souto Barreto, I Ader… - The Journal of …, 2020 - Springer
The Geroscience aims at a better understanding of the biological processes of aging, to
prevent and/or delay the onset of chronic diseases and disability as well as to reduce the …

[HTML][HTML] Key signaling pathways in aging and potential interventions for healthy aging

M Yu, H Zhang, B Wang, Y Zhang, X Zheng, B Shao… - Cells, 2021 - mdpi.com
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …