DNA methylation clocks for dogs and humans

S Horvath, AT Lu, A Haghani… - Proceedings of the …, 2022 - National Acad Sciences
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

Epigenetic clock and methylation studies in cats

K Raj, B Szladovits, A Haghani, JA Zoller, CZ Li… - GeroScience, 2021 - Springer
Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

Epigenetic clock and methylation studies in elephants

NA Prado, JL Brown, JA Zoller, A Haghani, M Yao… - Aging cell, 2021 - Wiley Online Library
Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

[HTML][HTML] An epigenetic aging clock for dogs and wolves

MJ Thompson, S Horvath, M Pellegrini - Aging (Albany NY), 2017 - ncbi.nlm.nih.gov
Several articles describe highly accurate age estimation methods based on human DNA-
methylation data. It is not yet known whether similar epigenetic aging clocks can be …

Development of epigenetic clocks for key ruminant species

A Caulton, KG Dodds, KM McRae, C Couldrey… - Genes, 2021 - mdpi.com
Robust biomarkers of chronological age have been developed in humans and model
mammalian species such as rats and mice using DNA methylation data. The concept of …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - BioRxiv, 2021 - biorxiv.org
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

[HTML][HTML] A multi-tissue full lifespan epigenetic clock for mice

MJ Thompson, K Chwiałkowska, L Rubbi… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

DNA methylation age analysis of rapamycin in common marmosets

S Horvath, JA Zoller, A Haghani, AT Lu, K Raj… - GeroScience, 2021 - Springer
Human DNA methylation data have previously been used to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Subsequent studies demonstrate that similar …

DNA methylation aging clocks: challenges and recommendations

CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck… - Genome biology, 2019 - Springer
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Multi-tissue DNA methylation age predictor in mouse

TM Stubbs, MJ Bonder, AK Stark, F Krueger… - Genome biology, 2017 - Springer
Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …