Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

DNA-methylation profiles have been used successfully to develop highly accurate
biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array …

Methylation levels at specific CpG positions in the genome have been used to develop
accurate estimators of chronological age in humans, mice, and other species. Although …

A global DNA hypomethylation and local changes in the methylation levels of specific DNA
loci occur during aging in mammals. Global hypomethylation mainly affects highly …

Age-associated DNA methylation reflects aspect of biological aging—therefore epigenetic
clocks for mice can elucidate how the aging process in this model organism is affected by …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

Biomarkers for holistic animal welfare monitoring represent a considerable unmet need in
veterinary medicine. Epigenetic modifications, like DNA methylation, provide important …

DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals
and levels are known to change with age. Recent studies have used DNAm changes as a …