Young blood plasma is known to confer beneficial effects on various organs in mice.
However, it was not known whether young plasma rejuvenates cells and tissues at the …

Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …

Aging is associated with dramatic changes to DNA methylation (DNAm), although the
causes and consequences of such alterations are unknown. Our ability to experimentally …

Epigenetic clocks based on patterns of DNA methylation have great importance in
understanding aging and disease; however, there are basic questions to be resolved in their …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Background Cytosine DNA methylation is a heritable epigenetic mark present in most
eukaryotic groups. While the patterns and functions of DNA methylation have been …

Background Epigenetic marks are encoded by DNA methylation and accumulate errors as
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …

Although epigenetic processes have been linked to aging and disease in other systems, it is
not yet known whether they relate to reproductive aging. Recently, we developed a highly …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …