Psychiatric disorders, morbidity, and mortality: tracing mechanistic pathways to accelerated aging

JK Kiecolt-Glaser, SJ Wilson - Psychosomatic medicine, 2016 - journals.lww.com
A meta-analysis published in this issue of Psychosomatic Medicine provides convincing
evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric …

Telomere length in psychiatric disorders: Is it more than an ageing marker?

N Monroy-Jaramillo, E Dyukova… - The World Journal of …, 2018 - Taylor & Francis
Objectives: Psychiatric and substance-use disorders have been associated with premature
biological ageing. Telomere length (TL), considered an ageing marker, has been analysed …

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging

NM Simon, JW Smoller, KL McNamara, RS Maser… - Biological …, 2006 - Elsevier
BACKGROUND: Little is known about the biological mechanisms underlying the excess
medical morbidity and mortality associated with mood disorders. Substantial evidence …

The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons

SM Darrow, JE Verhoeven, D Révész… - Psychosomatic …, 2016 - journals.lww.com
Objective This study examined the relationship between leukocyte telomere length (LTL), a
marker of cell aging, and psychiatric disorders in adults compared with controls using meta …

Psychiatric disorders and leukocyte telomere length: underlying mechanisms linking mental illness with cellular aging

D Lindqvist, ES Epel, SH Mellon, BW Penninx… - Neuroscience & …, 2015 - Elsevier
Many psychiatric illnesses are associated with early mortality and with an increased risk of
developing physical diseases that are more typically seen in the elderly. Moreover, certain …

Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder

I Shalev, TE Moffitt, AW Braithwaite, A Danese… - Molecular …, 2014 - nature.com
There is evidence that persistent psychiatric disorders lead to age-related disease and
premature mortality. Telomere length has emerged as a promising biomarker in studies that …

Epigenetic aging in psychiatry: clinical implications and therapeutic opportunities

CNC Lima, GR Fries - Neuropsychopharmacology, 2023 - nature.com
Patterns of accelerated aging have been reported in severe psychiatric disorders and are
hypothesized to underlie many poor health outcomes, including higher rates of chronic …

[HTML][HTML] Telomere biology in mood disorders: an updated, comprehensive review of the literature

A Muneer, FA Minhas - Clinical Psychopharmacology and …, 2019 - ncbi.nlm.nih.gov
Major psychiatric disorders are linked to early mortality and patients afflicted with these
ailments demonstrate an increased risk of developing physical diseases that are …

Telomere shortening and psychiatric disorders: a systematic review

PA Pousa, RM Souza, PHM Melo, BHM Correa… - Cells, 2021 - mdpi.com
Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of
this study was to evaluate whether psychiatric disorders marked by psychological distress …

[HTML][HTML] Telomere length associations with clinical diagnosis, age, and polygenic risk scores for anxiety disorder, depression, and bipolar disorder

J Mutz, CM Lewis - Biological Psychiatry Global Open Science, 2023 - Elsevier
Background Accelerated biological aging might contribute to the lower life expectancy of
individuals with mental disorders. The aim of this study was to characterize telomere length …