Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …

Purpose To evaluate the utility of 5-Item Modified Frailty Index (mFI-5) as compared to
chronological age in predicting outcomes of spinal osteotomy in Adult Spinal Deformity …

Background The epigenetic clock, in particular epigenetic pre-aging quantified by the so-
called DNA methylation age acceleration, has recently been suggested to closely correlate …

The mechanism of aging is not yet fully understood. It has been recognized that there are
age-dependent changes in the DNA methylation pattern of the whole genome. To date …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Background Epigenetic clocks constructed from DNA methylation patterns have emerged as
excellent predictors of aging and aging-related health outcomes. Iron, a crucial element, is …

Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …

Background DNA methylation analysis has proven to be a powerful tool for age assessment.
However, the implementation of epigenetic age prediction in diagnostics or routine forensic …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …