Background The biological mechanisms underlying frailty in older people are poorly
understood. There is some evidence to suggest that DNA methylation patterns may be …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Aging is the process of gradual physiological deterioration till death and this process
perpetually reduce the functionality of an individual. To address the rationale and provide …

Background A rapidly expanding literature suggests that individuals of the same
chronological age show significant variation in biological age. Purpose The purpose of this …

Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …

Introduction The proportion of older adults within society is sharply increasing and a better
understanding of how we age starts to be critical. However, given the paucity of longitudinal …

BACKGROUND CONTEXT: Adequate preoperative risk stratification is essential for surgical
planning and preoperative patient counseling, especially for operations known to have a …

As healthspan and lifespan research breakthroughs have become more commonplace, the
need for valid, practical markers of biological age is becoming increasingly paramount. The …

Epigenetic clocks are among the most promising biomarkers of aging. It is particularly
important to establish biomarkers of brain aging to better understand neurodegenerative …

DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker
of human ageing and a risk factor for age-related diseases. Despite different tissues having …