An epigenetic clock for human skeletal muscle
Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …
epigenetic markers can estimate chronological age based on DNA methylation patterns …
A meta-analysis of genome-wide association studies of epigenetic age acceleration
'Epigenetic age acceleration'is a valuable biomarker of ageing, predictive of morbidity and
mortality, but for which the underlying biological mechanisms are not well established. Two …
mortality, but for which the underlying biological mechanisms are not well established. Two …
Increased scalability and sequencing quality of an epigenetic age prediction assay
Epigenetic ageing in a human context, has been used to better understand the relationship
between age and factors such as lifestyle and genetics. In an ecological setting, it has been …
between age and factors such as lifestyle and genetics. In an ecological setting, it has been …
The association of epigenetic age acceleration and multimorbidity at age 90 in the Women's Health Initiative
Background Epigenetic age acceleration (EAA), a measure of accelerated biological aging,
has been associated with an increased risk of several age-related chronic conditions. This is …
has been associated with an increased risk of several age-related chronic conditions. This is …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
Comparative analysis of epigenetic aging clocks from CpG characteristics to functional associations
To date, a number of epigenetic clocks have been developed using DNA methylation data,
aimed at approximating biological aging in multiple tissues/cells. However, despite the …
aimed at approximating biological aging in multiple tissues/cells. However, despite the …
Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults
Gerontological research reveals considerable interindividual variability in aging phenotypes,
which has motivated research efforts to identify “aging biomarkers.” Aging biomarkers are …
which has motivated research efforts to identify “aging biomarkers.” Aging biomarkers are …
DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
Wandering along the epigenetic timeline
C Topart, E Werner, PB Arimondo - Clinical epigenetics, 2020 - Springer
Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …