DNA methylation has been implied to play a role in the immune dysfunction associated with
inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC) …

Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential
colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between …

Introduction Aberrant DNA methylation frequently occurs in the inflammatory mucosa in
ulcerative colitis (UC) and is involved in UC-related tumorigenesis. We performed …

Background DNA methylation constitutes a key epigenetic mechanism by which cells
regulate gene transcription. Among its roles are the dynamic regulation of gene expression …

Abstract Background and Aims: Inflammatory bowel diseases (IBDs) are heterogeneous
disorders with complex aetiology. Quantitative genetic studies suggest that only a small …

BACKGROUND: DNA methylation is considered one of the epigenetic mechanisms believed
to play a role in the pathogenesis of ulcerative colitis (UC). The aim of this study was to …

Abstract Background and Aims The aim of this study was to investigate the genome-wide
DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the …

Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel
disease patients reflect inflammatory status rather than disease status. Here, we examined …

The cause of inflammatory bowel disease (IBD) is still unknown, but there is growing
evidence that environmental factors such as epigenetic changes can contribute to the …

Abnormal DNA methylation has been described in human inflammatory conditions of the
gastrointestinal tract, such as inflammatory bowel disease (IBD). As other complex diseases …