This article investigates the effect on the mouse frailty index (FI), of factors known to
influence lifespan and healthspan in mice: strain (short-lived DBA/2J mice vs long-lived …

We investigated the reliability of a newly developed clinical frailty index (FI) that measures
frailty based on deficit accumulation in aging mice. FI scores were measured by two different …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

Frailty is a clinical syndrome associated with the aging process and adverse outcomes. The
purpose of this short report was to initiate the development of a Frailty Index in 27-to 28 …

Frailty is a clinical syndrome that is increasingly prevalent during aging. Frailty involves the
confluence of reduced strength, speed, physical activity, and endurance and is associated …

Rats are a commonly used model for aging studies, and a frailty assessment tool for rats
would be of considerable value. There has been a recent focus on the development of …

The mouse clinical frailty index and the mouse frailty phenotype assessment are two
recently developed tools used to assess frailty in mice. The objectives of this study were to …

Human life expectancy has increased dramatically in the last century and as a result also the
prevalence of a variety of age-related diseases and syndromes. One such syndrome is …

Although frailty has been extensively investigated for the last 2 decades, preclinical models
of frailty have only been developed over the past decade. Frailty is a concept that helps to …

Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …