Understanding the progression of early human embryonic development prior to implantation
is of fundamental biological importance. Greater insights into early developmental events …

Abstract Development of the mammalian embryo begins with formation of the totipotent
zygote during fertilization. This initial cell is able to give rise to every embryonic tissue of the …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

The basic body plan of the mammalian embryo is established through gastrulation, a pivotal
early postimplantation event during which the three major germ layers (endoderm …

Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

Technical and ethical limitations create a challenge to study early human development,
especially following the first 3 weeks of development after fertilization, when the fundamental …

Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture,,,. We report here a comprehensive analysis of …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Pre-implantation embryo development is an intricate and precisely regulated process
orchestrated by maternally inherited proteins and newly synthesized proteins following …

Over the past two decades, our understanding of mouse development from implantation to
gastrulation has grown exponentially with an upsurge of genetic, molecular, cellular, and …