Childhood psychiatric disorders are rarely static; rather they change over time and
longitudinal studies are ideally suited to capture such dynamic processes. Using …

Many cognitive, emotional and behavioural traits, as well as psychiatric disorders are highly
heritable. However, identifying the specific genes and mechanisms by which this heritability …

Neurodevelopmental models for the pathology of schizophrenia propose both polygenetic
and environmental risks, as well as early (pre/perinatal) and late (usually adolescent) …

OBJECTIVE: To review the maturational events that occur during prenatal and postnatal
brain development and to present neuroimaging findings from studies of healthy individuals …

The advent of magnetic resonance imaging, which safely allows in vivo quantification of
anatomical and physiological features of the brain, has revolutionized pediatric …

Background: Previous NIMH childhood onset schizophrenia (COS) anatomic brain MRI
studies found progression of ventricular volume and other structural brain anomalies at 2 …

Structural brain abnormalities have become an established feature of schizophrenia and
increasing evidence points towards the progressive nature of these abnormalities. The brain …

Background The symptom profile and neuropsychological functioning of individuals with
Attention Deficit/Hyperactivity Disorder (ADHD), change as they enter adolescence. It is …

Many psychiatric disorders, including some with adult onset such as schizophrenia, are
increasingly being conceptualized as stemming from anomalies of neurodevelopment. To …

Neurodevelopmental models of schizophrenia that identify longitudinal precursors of illness
have been of great heuristic importance, focusing mostly on etiologic research during the …