Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

Aging is a multifaceted process characterized by genetic and epigenetic changes in the
genome. The genetic component of aging received initially all of the attention. Telomere …

The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

The role of epigenetics in aging and age-related diseases is a key issue in molecular
physiology and medicine because certain epigenetic factors are thought to mediate, at least …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

A global DNA hypomethylation and local changes in the methylation levels of specific DNA
loci occur during aging in mammals. Global hypomethylation mainly affects highly …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …