DNA methylation in colorectal cancer—impact on screening and therapy monitoring modalities?

M Zitt, M Zitt, HM Müller - Disease markers, 2007 - Wiley Online Library
Colorectal cancer (CRC) is a common malignancy. It arises from benign neoplasms and
evolves into adenocarcinomas through a stepwise histological progression sequence …

DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

[HTML][HTML] DNA methylation assay for colorectal carcinoma

JJ Chen, AQ Wang, QQ Chen - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
Colorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide. Two
pathogenic pathways are involved in the development of adenoma to CRC. The first …

DNA methylation markers in colorectal cancer

MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer

Y Hashimoto, TJ Zumwalt, A Goel - Epigenomics, 2016 - Taylor & Francis
Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …

DNA methylation biomarkers of stool and blood for early detection of colon cancer

L Hong, N Ahuja - Genetic testing and molecular biomarkers, 2013 - liebertpub.com
Detection of colorectal cancer at an early stage may significantly decrease mortality from the
disease. The current screening test of colonoscopy is of high efficacy, but its acceptance in …

DNA methylation, a biomarker for colorectal cancer: implications for screening and pathological utility

AM Jubb, P Quirke, AJ Oates - … of the New York Academy of …, 2003 - Wiley Online Library
Currently up to one‐third of colorectal cancer patients present with locally advanced or
metastatic disease that precludes a surgical cure. Performance limitations and low uptake of …

[HTML][HTML] Accumulation of aberrant DNA methylation during colorectal cancer development

E Sakai, A Nakajima, A Kaneda - World Journal of …, 2014 - ncbi.nlm.nih.gov
Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples

EA Laugsand, SS Brenne, F Skorpen - International Journal of Colorectal …, 2021 - Springer
Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers
for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for …

Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation

F Coppedè - Cancer letters, 2014 - Elsevier
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …