N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …
JJ Chen, AQ Wang, QQ Chen - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
Colorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide. Two pathogenic pathways are involved in the development of adenoma to CRC. The first …
MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …
Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …
L Hong, N Ahuja - Genetic testing and molecular biomarkers, 2013 - liebertpub.com
Detection of colorectal cancer at an early stage may significantly decrease mortality from the disease. The current screening test of colonoscopy is of high efficacy, but its acceptance in …
AM Jubb, P Quirke, AJ Oates - … of the New York Academy of …, 2003 - Wiley Online Library
Currently up to one‐third of colorectal cancer patients present with locally advanced or metastatic disease that precludes a surgical cure. Performance limitations and low uptake of …
E Sakai, A Nakajima, A Kaneda - World Journal of …, 2014 - ncbi.nlm.nih.gov
Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains to be one of the most common causes of cancer-related death. CRC arises through …
EA Laugsand, SS Brenne, F Skorpen - International Journal of Colorectal …, 2021 - Springer
Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for …
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …