Molecular genetics of Alzheimer's disease

PH St George-Hyslop - Biological psychiatry, 2000 - Elsevier
Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Molecular genetics of Alzheimer's disease: the role of β-amyloid and the presenilins

A Tandon, E Rogaeva, M Mullan… - Current Opinion in …, 2000 - journals.lww.com
Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

Genetic susceptibility to Alzheimer disease

MA Pericak-Vance, JL Haines - Trends in genetics, 1995 - cell.com
Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade
ago, it was questioned as to whether or not genes were even involved in anything but rare …

Genetic studies in Alzheimer's disease

YP Tang, ES Gershon - Dialogues in clinical neuroscience, 2003 - Taylor & Francis
Alzheimer's disease (AD), the most common cause of dementia in aged populations, is
believed to be caused by both environmental factors and genetic variations. Extensive …

The genetics of Alzheimer disease: current status and future prospects

D Blacker, RE Tanzi - Archives of Neurology, 1998 - jamanetwork.com
Four genes involved in the development of Alzheimer disease have been identified. Three
fully penetrant (deterministic) genes lead to the development of Alzheimer disease in …

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

[HTML][HTML] Molecular biology and genetics of Alzheimer's disease

PH St George-Hyslop, A Petit - Comptes rendus biologies, 2005 - Elsevier
Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a
multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have …

Exploring the etiology of Alzheimer disease using molecular genetics

CL Lendon, F Ashall, AM Goate - Jama, 1997 - jamanetwork.com
Alzheimer disease (AD), the most common cause of dementia in the elderly, exists in both
familial and sporadic forms. Genetic studies have led to the identification of 3 genes, β …

Molecular genetics of Alzheimer's disease: an update

N Brouwers, K Sleegers, C Van Broeckhoven - Annals of medicine, 2008 - Taylor & Francis
Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

Genetics of Alzheimer's disease

MEA Vilatela, M López-López… - Archives of medical …, 2012 - Elsevier
Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …