[HTML][HTML] A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk
Biological age (BA), a measure of functional capacity and prognostic of health outcomes that
discriminates between individuals of the same chronological age (chronAge), has been …
discriminates between individuals of the same chronological age (chronAge), has been …
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
The aging process is characterized by the presence of high interindividual variation between
individuals of the same chronical age prompting a search for biomarkers that capture this …
individuals of the same chronical age prompting a search for biomarkers that capture this …
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …
as 'epigenetic clocks', which have been widely used to identify differences between …
DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging
Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …
on patterns of DNA methylation—can be computed and is associated with an array of factors …
Back to the future: epigenetic clock plasticity towards healthy aging
K Declerck, WV Berghe - Mechanisms of ageing and development, 2018 - Elsevier
Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
A meta-analysis of genome-wide association studies of epigenetic age acceleration
'Epigenetic age acceleration'is a valuable biomarker of ageing, predictive of morbidity and
mortality, but for which the underlying biological mechanisms are not well established. Two …
mortality, but for which the underlying biological mechanisms are not well established. Two …
A comparison of epigenetic mitotic-like clocks for cancer risk prediction
AE Teschendorff - Genome Medicine, 2020 - Springer
Background DNA methylation changes that accrue in the stem cell pool of an adult tissue in
line with the cumulative number of cell divisions may contribute to the observed variation in …
line with the cumulative number of cell divisions may contribute to the observed variation in …