The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
Systematic underestimation of the epigenetic clock and age acceleration in older subjects
Abstract Background The Horvath epigenetic clock is widely used. It predicts age quite well
from 353 CpG sites in the DNA methylation profile in unknown samples and has been used …
from 353 CpG sites in the DNA methylation profile in unknown samples and has been used …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
Clock work: Deconstructing the epigenetic clock signals in aging, disease, and reprogramming
Epigenetic clocks have come to be regarded as powerful tools for estimating aging.
However, a major drawback in their application is our lack of mechanistic understanding. We …
However, a major drawback in their application is our lack of mechanistic understanding. We …
DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4
Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …
Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Background DNA methylation-based biological age (DNAm age) is an important biomarker
for adult health. Studies in specific age ranges have found widely varying results about its …
for adult health. Studies in specific age ranges have found widely varying results about its …