Unraveling the mechanisms by which neural stem cells generate distinct cell types remains
a central challenge in central nervous system (CNS) biology. Recent studies have shown …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Epigenetic processes in the brain involve the transfer of information arising from short-lived
cellular signals and changes in neuronal activity into lasting effects on gene expression. Key …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Many cellular constituents in the human brain permanently exit from the cell cycle during pre-
or early postnatal development, but little is known about epigenetic regulation of neuronal …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

In many cell types, differentiation requires an interplay between extrinsic signals and
transcriptional changes mediated by repressive and activating histone modifications …

Brain function depends on interaction of diverse cell types whose gene expression and
identity are defined, in part, by epigenetic mechanisms. Neuronal DNA contains two major …

Transcriptional activation is a highly synchronized process in eukaryotes that requires a
series of cis-and trans-acting elements at promoter regions. Epigenetic modifications, such …

Defects in neurogenesis alter brain circuit formations and may lead to neurodevelopmental
disorders such as autism and schizophrenia. Histone H2A. z, a variant of histone H2A, plays …