It is well established that the regulation of epigenetic factors, including chromatic
reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for …

Highlights•Chd chromatin remodeling enzymes govern distinct phases of neuronal
connectivity.•Chd4 orchestrates afferent and efferent neuronal connectivity via distinct …

The complexity of the human brain emerges from a long and finely tuned developmental
process orchestrated by the crosstalk between genome and environment. Vis à vis other …

Molecular modifications to the structure of histone proteins and DNA (chromatin) play a
significant role in regulating the transcription of genes without altering their nucleotide …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

In multicellular organisms, all the cells are genetically identical but turn genes on or off at the
right time to promote differentiation into specific cell types. The regulation of higher-order …

Over the past decade, rapid advances in epigenomics research have extensively
characterized critical roles for chromatin regulatory events during normal periods of …

Epigenetics allows for the inheritance of information in cellular lineages during
differentiation, independent of changes to the underlying genetic sequence. This raises the …