Cerebrospinal fluid and plasma biomarkers in neurodegenerative diseases

Y Seino, T Nakamura, T Kawarabayashi… - Journal of …, 2019 - content.iospress.com
Cerebrospinal fluid (CSF) amyloid-β (Aβ) 42 and tau are biomarkers for Alzheimer's disease
(AD); however, the effects of other neurodegenerative processes on these biomarkers …

Stage-dependent agreement between cerebrospinal fluid proteins and FDG-PET findings in Alzheimer's disease

I Yakushev, MJ Muller, HG Buchholz… - Current Alzheimer …, 2012 - ingentaconnect.com
Cerebral hypometabolism and abnormal levels of amyloid beta (Aβ), total (t-tau) and
phosphorylated tau (ptau) proteins in cerebrospinal fluid (CSF) are established biomarkers …

Characterizing amyloid-positive individuals with normal tau PET levels after 5 years: An ADNI study

KA Josephs, SD Weigand, JL Whitwell - Neurology, 2022 - AAN Enterprises
Background and Objective Individuals with biomarker evidence of β-amyloid (Aβ) deposition
are increasingly being enrolled in clinical treatment trials but there is a need to identify …

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer's disease

V Welge, O Fiege, P Lewczuk, B Mollenhauer… - Journal of neural …, 2009 - Springer
Cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ) 1-38, 1-40, 1-42, total-tau and
phospho-tau in samples from 156 patients with Alzheimer's disease (AD)(n= 44), depressive …

CSF-tau, CSF-Aß1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity …

S Ganzer, S Arlt, V Schoder, C Buhmann… - Journal of neural …, 2003 - Springer
This study evaluated the sensitivity and specificity of the cerebrospinal fluid (CSF) levels of
tau-protein, amyloid-ß-peptide 1-42 (Aß1-42), ApoE-genotype and the degree of cognitive …

Cerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia

C Oboudiyat, T Gefen, E Varelas, S Weintraub… - Alzheimer's & …, 2017 - Elsevier
Introduction The accuracy of cerebrospinal fluid (CSF) biomarkers for detecting Alzheimer's
disease (AD) pathology has not been fully validated in autopsied nonamnestic dementias …

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

CR Jack Jr, HJ Wiste, SD Weigand, DS Knopman… - Brain, 2015 - academic.oup.com
We recently demonstrated that the frequencies of biomarker groups defined by the presence
or absence of both amyloidosis (A+) and neurodegeneration (N+) changed dramatically by …

[HTML][HTML] P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles

KEJ Wesenhagen, BM Tijms, L Boonkamp… - Alzheimer's Research & …, 2022 - Springer
Background We previously identified four Alzheimer's disease (AD) subgroups with
increasingly higher cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 181 …

Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum

DS Knopman, CR Jack Jr, ES Lundt, SD Weigand… - Neurobiology of …, 2016 - Elsevier
The availability of antemortem biomarkers for Alzheimer's disease (AD) enables monitoring
the evolution of neurodegenerative processes in real time. Pittsburgh compound B (PIB) …

[HTML][HTML] Age, vascular disease, and Alzheimer's disease pathologies in amyloid negative elderly adults

T Guo, SM Landau, WJ Jagust… - Alzheimer's Research & …, 2021 - Springer
Background We recently reported that CSF phosphorylated tau (p-Tau 181) relative to Aβ 40
(CSF p-Tau/Aβ 40 ratio) was less noisy and increased associations with Alzheimer's disease …