Drosophila has long been a successful model organism in multiple fields such as genetics
and developmental biology. Drosophila genome is relatively smaller and less redundant, yet …

Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

The development of a multicellular organism is a highly intricate process tightly regulated by
numerous genes and pathways in both spatial and temporal manners. Here, we present …

Cells do not live in a vacuum, but in a milieu defined by cell–cell communication that can be
measured via emerging high-resolution spatial transcriptomics approaches. However …

During development, positional information directs cells to specific fates, leading them to
differentiate with their own transcriptomes and express specific behaviors and functions …

Complex spatial and temporal patterns of gene expression underlie embryo differentiation,
yet methods do not yet exist for the efficient genome-wide determination of spatial …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Drosophila melanogaster is a powerful, long-standing model for metazoan development and
gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression …

In this thesis, we present an innovative framework centered around the application of
Random Forest Regression to forecast the prospective distribution of cells expressing the …

The embryonic nervous system of Drosophila melanogaster derives from the neurogenic
ectoderm, which is subdivided into three distinct domains. Several key transcription factors …