'Accelerated aging': a primrose path to insight?

RA Miller - Aging cell, 2004 - Wiley Online Library
Organism envy afflicts most researchers who work on aging in mice; how frustrating it is to
see the worm and fly biologists nail down milestone after milestone, citation after citation …

From discoveries in ageing research to therapeutics for healthy ageing

J Campisi, P Kapahi, GJ Lithgow, S Melov, JC Newman… - Nature, 2019 - nature.com
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

How genetic analysis tests theories of animal aging

S Hekimi - Nature genetics, 2006 - nature.com
Each animal species displays a specific life span, rate of aging and pattern of development
of age-dependent diseases. The genetic bases of these related features are being studied …

We need to shift the focus of aging research to aging itself

JR Poganik, VN Gladyshev - Proceedings of the National …, 2023 - National Acad Sciences
The field of aging is at a precipice. Attention and funding are increasingly focused on this
area, and exciting, fundamentally important findings are being reported literally every day …

Animal and human models to understand ageing

H Lees, H Walters, LS Cox - Maturitas, 2016 - Elsevier
Human ageing is the gradual decline in organ and tissue function with increasing
chronological time, leading eventually to loss of function and death. To study the processes …

[HTML][HTML] What if there's no such thing as “aging”?

AA Cohen, V Legault, T Fülöp - Mechanisms of ageing and development, 2020 - Elsevier
Are diseases caused by aging? What are the mechanisms of aging? Do all species age?
These hotly debated questions revolve around a unitary definition of aging. Because we use …

The new science of ageing

L Partridge, J Thornton, G Bates - … Transactions of the …, 2011 - royalsocietypublishing.org
Thanks to improvements in hygiene and healthcare, human life expectancy in developed
countries has been increasing at a steady rate of about 2.5 years per decade since the …

Horizons in the evolution of aging

T Flatt, L Partridge - BMC biology, 2018 - Springer
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Aging research—where do we stand and where are we going?

L Guarente - Cell, 2014 - cell.com
The 40 th anniversary of Cell coincides with that of the National Institute on Aging (NIA).
Indeed, Cell papers on NIA-funded research helped move the field into a genetic and …

Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology

HR Warner, F Sierra - Mechanisms of ageing and development, 2003 - Elsevier
During the past ten years considerable progress has been made in discovering genes that
regulate longevity by identifying single gene mutations that lead to increased longevity. The …