Metazoan development involves the successive activation and silencing of specific gene
expression programs and is driven by tissue-specific transcription factors programming the …

How overall principles of cell-type–specific gene regulation (the “logic”) may change during
ontogeny is largely unexplored. We compared transcriptomic, epigenomic, and three …

During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …

Around implantation, the epiblast (Epi) transits from naïve to primed pluripotency, before
giving rise to the three germ layers. How chromatin is reconfigured during this …

Over the past two to three decades, developmental biology has demonstrated that all
multicellular organisms in the animal kingdom share many of the same molecular building …

The generation of distinctive cell types that form different tissues and organs requires
precise, temporal and spatial control of gene expression. This depends on specific cis …

Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and
primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early …

During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …

Chromosome conformation is an important feature of metazoan gene regulation,; however,
enhancer–promoter contact remodeling during cellular differentiation remains poorly …

Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …