Fueled by recent advances in single cell biology, we are moving away from qualitative and
undersampled assessments of cell identity, toward building quantitative, high-resolution cell …

A common metaphor for describing development is a rugged “epigenetic landscape” where
cell fates are represented as attracting valleys resulting from a complex regulatory network …

Most cells contain the same set of genes and yet they are extremely diverse in appearance
and functions. It is the selective expression and repression of genes that determines the …

Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …

Evolutionary cell biology explores the origins, principles, and core functions of cellular
features and regulatory networks through the lens of evolution. This emerging field relies …

Intercellular communication is essential to coordinate the behaviour of individual cells
during organismal development. The preimplantation mammalian embryo is a paradigm of …

Background Mouse has served as an excellent model for studying human development and
diseases due to its similarity to human. Advances in transgenic and knockout studies in …

For decades, Waddington's concept of the'epigenetic landscape'has served as an educative
hierarchical model to illustrate the progressive restriction of cell differentiation potential …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

Yamanaka factors are essential for establishing pluripotency in embryonic stem cells, but
their function in multipotent stem cell populations is poorly understood. Here, we show that …