Biological age (BA), derived from molecular and physiological measurements, has been
proposed to better predict mortality and disease than chronological age (CA). In the present …

Our understanding of the mechanisms by which aging is produced is still very limited. Here,
we have determined the sera metabolite profile of 117 wild‐type mice of different genetic …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …

Multiple recent advances in machine learning enabled computer systems to exceed human
performance in many tasks including voice, text, and speech recognition and complex …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

We previously identified 529 proteins that had been reported by multiple different studies to
change their expression level with age in human plasma. In the present study, we measured …