Accurate and physiologically meaningful biomarkers for human aging are key to assessing
antiaging therapies. Given ethnic differences in health, diet, lifestyle, behavior …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

Understanding why we age is a long-standing question, and many mechanistic theories of
aging have been proposed. Owing to limitations in studying the aging process, including a …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of
human populations grows steadily older, the impact of this risk factor grows as well …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …

Epigenetic clocks have come to be regarded as powerful tools for estimating aging.
However, a major drawback in their application is our lack of mechanistic understanding. We …

One of the major impediments in human aging research is the absence of a comprehensive
and actionable set of biomarkers that may be targeted and measured to track the …