Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer's disease

C Liu, S Xu, Q Liu, H Chai, Y Luo, S Li - BMC Medical Genomics, 2023 - Springer
Alzheimer's disease (AD) is the most prevalent cause of dementia and is primarily
associated with memory impairment and cognitive decline, but the etiology of AD has not …

Discovery and validation of key biomarkers based on immune infiltrates in Alzheimer's disease

Z Liu, H Li, S Pan - Frontiers in Genetics, 2021 - frontiersin.org
Background As the most common neurodegenerative disease, Alzheimer's disease (AD)
leads to progressive loss of cognition and memory. Presently, the underlying pathogenic …

[HTML][HTML] Identification of immune cells and key genes associated with Alzheimer's disease

C Liu, X Zhang, H Chai, S Xu, Q Liu… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive impairment and memory loss, for which there is no effective cure to date. In the …

Relationship between Alzheimer's disease and the immune system: a meta-analysis of differentially expressed genes

N Wang, Y Zhang, L Xu, S Jin - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD), a neurodegenerative diseases (neuro-diseases) which is
prevalent in the elderly and seriously affects the lives of individuals. Many studies have …

[HTML][HTML] Expression of immune related genes and possible regulatory mechanisms in Alzheimer's disease

Y Lu, K Li, Y Hu, X Wang - Frontiers in immunology, 2021 - frontiersin.org
Immune infiltration of peripheral natural killer (NK) cells in the brain has been observed in
Alzheimer's disease (AD). Immunity-related genes (IRGs) play an essential role in immune …

Development of a novel immune infiltration-related diagnostic model for Alzheimer's disease using bioinformatic strategies

X Zhuang, G Zhang, M Bao, G Jiang, H Wang… - Frontiers in …, 2023 - frontiersin.org
Background The pathogenesis of Alzheimer's disease (AD) is complex and multi-factorial.
Increasing evidence has shown the important role of immune infiltration in AD. Thus the …

[HTML][HTML] Immune abnormalities and differential gene expression in the hippocampus and peripheral blood of patients with Alzheimer's disease

X Wang, D Wang, F Su, C Li, M Chen - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background Despite decades of research, no precise mechanisms of Alzheimer's disease
(AD) development have been elucidated. This study aimed to investigate novel diagnostic …

Identification of biomarkers related to M2 macrophage infiltration in Alzheimer's disease

C Lin, C Xu, Y Zhou, A Chen, B Jin - Cells, 2022 - mdpi.com
Many studies have demonstrated that neuroinflammation contributes to the onset and
development of Alzheimer's disease (AD). The infiltration of immune cells in the brain was …

[HTML][HTML] Integrated bioinformatics-based identification of diagnostic markers in Alzheimer disease

D Chen, Y Zhang, R Qiao, X Kong, H Zhong… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer disease (AD) is a progressive neurodegenerative disease resulting from the
accumulation of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles …

Development and validation of immune-based biomarkers and deep learning models for Alzheimer's disease

Y He, L Cong, Q He, N Feng, Y Wu - Frontiers in genetics, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) is the most common form of dementia in old age and
poses a severe threat to the health and life of the elderly. However, traditional diagnostic …