Alzheimer's disease (AD) is the most common and devastating neurodegenerative disease
of the elderly. Many research findings on familial AD suggest that the mechanisms of the …

Genetic assessment is currently of limited utility in clinical practice because of the low
frequency (Mendelian mutations) or small effect size (common risk factors) of the currently …

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …

Publisher Summary Alzheimer disease (AD), the major form of senile dementia, is rapidly
becoming a major health problem in the developed countries since as populations live …

Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a
multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have …

Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade
ago, it was questioned as to whether or not genes were even involved in anything but rare …

Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Epidemiological and individual case studies indicate that genetic factors play a significant
role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families …

The genetics of Alzheimer's disease (AD) is complex. Three genes (amyloid precursor
protein, presenilin 1 and presenilin 2) have been described in the relatively rare, early …