Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning. Despite its basic and clinical importance, early human …

Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and
hypoblast. Here we describe a human embryo model (blastoid) generated by self …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

Recent studies show that pluripotent stem cells can undergo self-organized development in
vitro into structures that mimic the body plan of the post-implantation embryo. Modeling …