Progress in gerontological research has been promoted through the use of numerous
animal models, which have helped identify possible mechanisms of aging and age-related …

A graying human population and the rising costs of healthcare have fueled the growing
need for a sophisticated translational model of aging. Nonhuman primates (NHPs) …

A variety of animal models are utilized in biogerontological studies including yeast,
nematodes, fruit flies, hamsters, mice, rats, and nonhuman primates. Species selection for …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

Publisher Summary In invertebrates, the molecular genetic pathways that regulate life span
and senescence are being identified; surprisingly, they are conserved through evolution. In …

If effective anti-aging interventions are to be identified for human application, then the
development of reliable and valid biomarkers of aging are essential for this progress …

Aging is the biological process of declining physiologic function associated with increasing
mortality rate during advancing age. Humans and higher nonhuman primates exhibit …

Virtually, all research on basic mechanisms of aging has used species that are short lived
and thus demonstrably unsuccessful at combating basic aging processes. A novel …

Research in the basic biology of ageing is increasingly identifying mechanisms and
modifiers of ageing in short-lived organisms such as worms and mice. The ultimate goal of …

ADVANCES in the understanding of biological aging L depend on the availability of suitable
animals of appropriately diverse ages. A logical opinion shared by many gerontologists is …