Elucidating the lineage relationships among different cell types is key to understanding
human brain development. Here we developed parallel RNA and DNA analysis after deep …

Highlights•Single-cell RNA sequencing revolutionizes systematic classification of neurons.•
Classification by scRNA-seq reveals new neuronal subtypes.•Matching transcriptionally and …

Recent advances in single-cell RNA-sequencing technology have enabled us to
characterize a variety of different cell types in each brain region. However, the evolutionary …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

The mammalian brain is composed of diverse, specialized cell populations. To
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …

The mammalian brain is composed of diverse, specialized cell populations, few of which we
fully understand. To more systematically ascertain and learn from cellular specializations in …

Modern RNA sequencing methods have greatly increased our understanding of the
molecular fingerprint of neurons, astrocytes and oligodendrocytes throughout the central …

Single-cell RNA sequencing (scRNA-seq) is a widely used method for identifying cell types
and trajectories in biologically heterogeneous samples, but it is limited in its detection and …

Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …

The mammalian brain is characterized by distinct classes of cells that differ in morphology,
structure, signaling, and function. Dysregulation of gene expression in these cell populations …