Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

Recent discoveries in the science of ageing indicate that lifespan in model organisms such
as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Recent progress in the science of aging is driven largely by the use of model systems,
ranging from yeast and nematodes to mice. These models have revealed conservation in …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

It has long been assumed that lifespan and healthspan correlate strongly, yet the two can be
clearly dissociated,,,,–. Although there has been a global increase in human life expectancy …

Ageing is driven by a loss of transcriptional and protein homeostasis,, and is the key risk
factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …

The accumulation of stochastic DNA damage throughout an organism's lifespan is thought to
contribute to ageing. Conversely, ageing seems to be phenotypically reproducible and …