Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …

Old age is associated with a progressive decline of mitochondrial function and changes in
nuclear chromatin. However, little is known about how metabolic activity and epigenetic …

Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …

Despite recent progress in the identification of genes that regulate longevity, aging remains
a mysterious process. One influential hypothesis is the idea that the potential for cell division …

The study of human genetic disorders and mutant mouse models has provided evidence
that genome maintenance mechanisms, DNA damage signalling and metabolic regulation …

Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

An ageing world population has fuelled interest in regenerative remedies that may stem
declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

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Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human …