Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the
optimal life history, in which survival and fertility late in life are sacrificed for the sake of early …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects …

Driven by technological progress, human life expectancy has increased greatly since the
nineteenth century. Demographic evidence has revealed an ongoing reduction in old-age …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

During replicative aging of primary cells morphological transformations occur, the
expression pattern is altered and chromatin changes globally. Here we show that chronic …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Ageing is driven by a loss of cellular integrity. Given the major role of ubiquitin modifications
in cell function, here we assess the link between ubiquitination and ageing by quantifying …

Most human somatic cells can undergo only a limited number of population doublings in
vitro. This exhaustion of proliferative potential, called senescence, can be triggered when …

A central aspect of aging research concerns the question of when individuality in lifespan
arises. Here we show that a transient increase in reactive oxygen species (ROS), which …