Replicative crisis is a senescence-independent process that acts as a final barrier against
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …

At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for
this improbable union can actually be traced back to a sequence of tragic—and some say …

Chromatin structure orchestrates the accessibility to the genetic material. Replication-
independent histone variants control transcriptional plasticity in postmitotic cells. The life …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Are diseases caused by aging? What are the mechanisms of aging? Do all species age?
These hotly debated questions revolve around a unitary definition of aging. Because we use …

Ageing—the decline in survival and fecundity with advancing age—is caused by damage to
macromolecules and tissues. Ageing is not a programmed process, in the sense that no …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

The rate of behavioural decline in the ageing population is remarkably variable among
individuals. Despite the considerable interest in studying natural variation in ageing rate to …

The 40 th anniversary of Cell coincides with that of the National Institute on Aging (NIA).
Indeed, Cell papers on NIA-funded research helped move the field into a genetic and …

In the central nervous system, ageing results in a precipitous decline in adult neural
stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive …