Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms

MM Garvin, JL Bolton - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase
vulnerability to cognitive and emotional disorders. However, the importance of examining …

Early life adversity across different cell-types in the brain

G Warhaftig, D Almeida, G Turecki - Neuroscience & Biobehavioral …, 2023 - Elsevier
Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …

Early life adversity and neuropsychiatric disease: differential outcomes and translational relevance of rodent models

RC Waters, E Gould - Frontiers in systems neuroscience, 2022 - frontiersin.org
It is now well-established that early life adversity (ELA) predisposes individuals to develop
several neuropsychiatric conditions, including anxiety disorders, and major depressive …

Neurostructural traces of early life adversities: A meta-analysis exploring age-and adversity-specific effects

TM Pollok, A Kaiser, EJ Kraaijenvanger… - Neuroscience & …, 2022 - Elsevier
Early life adversities (ELAs) are associated with an increased risk of psychopathology, with
studies suggesting a relation to structural brain alterations. Given the recently growing …

Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

JA Honeycutt, C Demaestri, S Peterzell, MM Silveri… - Elife, 2020 - elifesciences.org
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

V Bonapersona, J Kentrop, CJ Van Lissa… - Neuroscience & …, 2019 - Elsevier
Altered cognitive performance is considered an intermediate phenotype mediating early life
adversity (ELA) effects on later-life development of mental disorders, eg depression …

Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

SC Levis, MT Birnie, JL Bolton, CR Perrone… - Translational …, 2022 - nature.com
In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is
linked to increased risk of later-life emotional disorders including depression and substance …

Early life adversity and health‐risk behaviors: proposed psychological and neural mechanisms

KA Duffy, KA McLaughlin… - Annals of the New York …, 2018 - Wiley Online Library
Early life adversity (ELA) is associated with poorer health in adulthood, an association
explained, at least in part, by increased engagement in health‐risk behaviors (HRBs). In this …

Mechanisms underlying the association between early-life adversity and physical health: charting a course for the future

NR Bush, RD Lane, KA McLaughlin - Psychosomatic medicine, 2016 - journals.lww.com
Early-life adversities (ELA) are associated with subsequent pervasive alterations across a
wide range of neurobiological systems and psychosocial factors that contribute to …

Type of early life adversity confers differential, sex-dependent effects on early maturational milestones in mice

C Demaestri, T Pan, M Critz, D Ofray, M Gallo… - Hormones and …, 2020 - Elsevier
Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …