Appreciation of the physiological relevance of mammalian adult neurogenesis has in recent
years rapidly expanded from a phenomenon of homeostatic cell replacement and brain …

Available evidences point to methionine metabolism as a key target to study the molecular
adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic …

Without healing, multicellular life on Earth would not exist. Without healing, one injury
predisposes to another, leading to disability, chronic disease, accelerated aging, and death …

Understanding the mechanisms behind neurodifferentiation in adults will be an important
milestone in our quest to identify treatment strategies for cognitive disorders observed during …

Neurodegeneration in mitochondrial disorders is considered irreversible because of limited
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Here we review the environmental and genetic manipulations that link cellular and
organismal metabolism to aging. In particular, we explore how nutrients are sensed and how …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …