A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

Significance: In humans, imbalances in the reduction–oxidation (redox) status of cells are
associated with many pathological states. In addition, many therapeutics and prophylactics …

Significance: Once considered to be mere by-products of metabolism, reactive oxygen,
nitrogen and sulfur species are now recognized to play important roles in diverse cellular …

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

Our daily intake of the 40 essential micronutrients—vitamins, minerals and other
biochemicals—is commonly thought to be adequate. Indeed, classic deficiency diseases …

Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

Accumulating evidence suggests the existence of a strong link between metabolic syndrome
and neurodegeneration. Indeed, epidemiologic studies have described solid associations …

It is well-established that mitochondria are the powerhouses of the cell, producing
adenosine triphosphate (ATP), the universal energy currency. However, the most significant …

Significance: Transsulfuration allows conversion of methionine into cysteine using
homocysteine (Hcy) as an intermediate. This pathway produces S-adenosylmethionine …

Oxidative stress and the generation of reactive oxygen species (ROS) can lead to
mitochondrial dysfunction, DNA damage, protein misfolding, programmed cell death with …