Mitochondria play a multidimensional role in the function and the vitality of the neurological
system. From the generation of neural stem cells to the maintenance of neurons and their …

DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral
glucose administration at advanced age increases health and lifespan of telomere …

Cellular metabolism assembles in a structurally highly conserved, but functionally dynamic
system, known as the metabolic network. This network involves highly active, enzyme …

Most of the drugs currently prescribed for cancer treatment are riddled with substantial side
effects. In order to develop more effective and specific strategies to treat cancer, it is of …

Neurodegenerative disorders are a major public health problem worldwide with huge
socioeconomic effect. Recent evidence suggests that neurodegeneration is not only caused …

Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively
cause cellular damage and lack a physiological function. Accumulation of ROS and …

All organisms need to be capable of adapting to changes in the availability and composition
of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Metabolic dysregulation is an appreciated hallmark of cancer and a target for therapeutic
intervention. Cellular metabolism involves a series of oxidation/reduction (redox) reactions …

In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …