Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …

Age-associated DNA methylation changes have been widely reported across many different
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …

Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …

Aging is characterized by a profound remodeling of the epigenetic architecture in terms of
DNA methylation patterns. To date the most effective tool to study genome wide DNA …

Background Chronological aging-associated changes in the human DNA methylome have
been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites …

Aging is a progressive process that results in the accumulation of intra-and extracellular
alterations that in turn contribute to a reduction in health. Age-related changes in DNA …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …

Epigenetic remodeling is one of the major features of the aging process. We recently
demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …