Epigenetic regulation plays an important role in controlling gene expression during complex
processes, such as development of the human brain. Mutations in genes encoding …

Highlights•Chromatin regulators orchestrate the pace and order of gene expression
programs in differentiating neurons.•Disease-associated mutations in chromatin regulators …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

A comprehensive characterization of epigenomic organization in the embryonic mouse
forebrain will enhance our understanding of neurodevelopment and provide insight into …

During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

Genetically diverse pluripotent stem cells display varied, heritable responses to
differentiation cues. Here, we harnessed these disparities through derivation of mouse …

Epigenetic changes, including histone modifications or chromatin remodeling are regulated
by a large number of human genes. We developed a strategy to study the coordinate …

During embryonic brain development, neurogenesis requires the orchestration of gene
expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with …

Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and
oligodendrocytes during mammalian brain development is a carefully controlled and timed …

Axon regeneration in adult central nervous system (CNS) is limited in part by a
developmental decline in the ability of injured neurons to re-express needed regeneration …