Epigenetic changes occur throughout life from embryonic development into adulthood. This
results in the timely expression of developmentally important genes, determining the …

Two critical properties of stem cells are self-renewal and multipotency. The maintenance of
their “stemness” state and commitment to differentiation are therefore tightly controlled by …

The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of
the adult brain. These cells self-renew and are multipotent. The maintenance of “stemness” …

Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial
cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This …

During development, neural progenitor cells (NPCs) that are capable of self-renewing
maintain a proliferative cellular pool while generating all differentiated neural cell …

The coordinated development of the nervous system requires fidelity in the expression of
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …

Development is a well-defined stage-to-stage process that allows the coordination and
maintenance of the structure and function of cells and their progenitors, in a complete …

Unraveling the mechanisms by which neural stem cells generate distinct cell types remains
a central challenge in central nervous system (CNS) biology. Recent studies have shown …

Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and
oligodendrocytes during mammalian brain development is a carefully controlled and timed …

Derived from neural stem cells (NSCs) and progenitor cells originated from the
neuroectoderm, the nervous system presents an unprecedented degree of cellular diversity …