Highlights•Single-cell RNA sequencing revolutionizes systematic classification of neurons.•
Classification by scRNA-seq reveals new neuronal subtypes.•Matching transcriptionally and …

Modern RNA sequencing methods have greatly increased our understanding of the
molecular fingerprint of neurons, astrocytes and oligodendrocytes throughout the central …

Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …

To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

The diversity of neuronal cell types and how to classify them are perennial questions in
neuroscience. The advent of global gene expression analysis raised the possibility that …

We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex.
Such categorization is a first step toward understanding how diversification relates to …

The classification of neurons into distinct types is an ongoing effort aimed at revealing and
understanding the diversity of the components of the nervous system. Recently available …

Highlights•Single-cell transcriptomics is a nearly universal approach to molecularly classify
neurons.•Sampling multiple developmental stages provides insights into the origin of cortical …

With the discovery of the incredible diversity of neurons, Cajal and coworkers laid the
foundation of modern neuroscience. Neuron types are not only structural units of nervous …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …