We provide evidence for multidirectionality, variability, and plasticity in the nature and
direction of change in physical health, cognitive functioning, and well-being during the …

Background There remains a dearth of life-course studies analyzing childhood environment
and late-life chronic illness. In particular, few have addressed possible early-life predictors of …

Recent neurodevelopmental and evolutionary theories offer strong theoretical rationales
and some empirical evidence to support the importance of specific dimensions of early …

Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Personal views on aging, such as age stereotypes and subjective aging, can affect various
health outcomes in later life. For the past 20 years or so, a large body of experimental and …

Objective To understand why children exposed to adverse psychosocial experiences are at
elevated risk for age-related disease, such as cardiovascular disease, by testing whether …

Exposure to toxic stress accelerates the wear and tear on children's developing bodies and
leaves a lasting mark on adult health. Prior research has focused mainly on children …

How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

Socially disadvantaged individuals are at greater risk for simultaneously being exposed to
adverse social and environmental conditions. Although the mechanisms underlying joint …

Aims: To investigate long term effects of early adverse circumstances on cognitive function.
Methods: Associations between early material home circumstances, parental divorce …