There is substantial debate in the field of epidemiology over the theoretical underpinnings of
socioeconomic status (SES)–disease mechanisms in the developed world. In particular, it …

There is increasing interest in discovering mechanisms that mediate the effects of childhood
stress on late-life disease morbidity and mortality. Previous studies have suggested one …

METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …

Epigenetic processes, including DNA methylation, change reliably with age across the
lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic …

This article focuses on cumulative adversity and protective resources, both social and
biological, that interrupt or deflect individuals from optimal life-course trajectories and …

Maturation of long-running birth cohort studies has fostered a life course approach to adult
health, function, and disease and related to conceptual frameworks. Using broad concepts …

Although the association between adverse childhood experiences (ACEs) and adult mental
health is becoming well established, less is known about the complex and multiple …

Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse
experiences, is associated with poor physical and mental health outcomes. To understand …