An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Objective: The current study examined the prospective effects of exposure to stressful
conditions in early childhood on physical health in young adulthood, and explored …

Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental
effects on daily‐life functioning, somatic health, and quality of life. An emerging perspective …

Background Studies of psychiatric populations have reported associations between
childhood adversity and volumes of stress-related brain structures. This meta-analysis …

PURPOSE: Prospective evidence about whether the association of childhood adversity and
psychopathology attenuates across the lifecourse and whether effects on mid-life …

Early adversity is a strong and enduring predictor of psychiatric disorders including mood
disorders, anxiety disorders, substance abuse or dependence, and posttraumatic stress …

Background The Adverse Childhood Experiences (ACE) Study is a major research study
that compares current adult health status to childhood experiences decades earlier. With the …

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical
health risks later in life. ELA has been associated with dysfunctional neurodevelopment …

Rationale The investigation of putative effects of early life stress (ELS) in humans on later
behavior and neurobiology is a fast developing field. While epidemiological and …

Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …