The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …

The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …

It is tempting to assume that a gradual accumulation of damage 'causes 'an organism to age,
but other biological processes present during the lifespan, whether 'programmed 'or …

Differences in health status by socioeconomic position (SEP) tend to be more evident at
older ages, suggesting the involvement of a biological mechanism responsive to the …

The rapid technological advancements achieved in the last years have boosted the
progressive identification of age-associated epigenetic changes. These studies not only …

As life expectancy increases worldwide, ageing and age-related diseases arise as a major
issue for societies around the globe. Understanding the biological mechanisms underlying …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …