Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

It is well established that genotype plays an important role in the ageing process. However,
recent studies have suggested that epigenetic mechanisms may also influence the onset of …

In this review, we summarize current knowledge regarding the epigenetics of age-related
diseases, focusing on those studies that have described DNA methylation landscape in …

The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors, and it is among the most complex phenotypes studied to date …

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …

Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Healthy aging has become a major goal of public health. Many studies have provided
evidence and theories to explain molecular mechanisms of the aging process. Recent …