Background Epigenetic clocks are promising tools for the study of aging in humans. The
clocks quantify biological aging above and beyond chronological age, demonstrate …

Given the myriad of age-related changes and the many proposed mechanistic theories of
ageing, a major problem in gerontology is distinguishing causes from effects. This review …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …

Aging is a multifaceted process characterized by genetic and epigenetic changes in the
genome. The genetic component of aging received initially all of the attention. Telomere …

Epigenetic age is an emerging marker of health that is highly predictive of disease and
mortality risk. There is a lack of evidence on whether lifestyle changes are associated with …

Markers of biological aging have potential utility in primary care and public health. We
developed a model of age based on untargeted metabolic profiling across multiple …

Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic
conditions and reduced life-expectancy, but the underlying biomolecular mechanisms …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …