Background Epigenetic age is an estimator of biological age based on DNA methylation; its
discrepancy from chronologic age warrants further investigation. We recently reported that …

The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded
the field of frailty, including social and behavioral domains with critical interaction between …

DNA methylation‐based age estimators (DNAm ageing clocks) are currently one of the most
promising biomarkers for predicting biological age. However, the relationships between …

Epigenetic drift and age-related methylation have both been used in the literature to
describe changes in DNA methylation that occurs with aging. However, ambiguity remains …

Purpose of Review DNA methylation-based aging biomarkers are valuable tools for
evaluating the aging process from a molecular perspective. These epigenetic aging …

The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …

Epigenetic changes during ageing have been characterized by multiple epigenetic clocks
that allow the prediction of chronological age based on methylation status. Despite their …

The view of aging has evolved in parallel with the advances in biomedical sciences. Long
considered as an irreversible process where interventions were only aimed at slowing down …

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …

The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …